DNA Methylation

Google DeepMind has released AlphaGenome 2, a next-generation genomic AI model built on a conditional architecture that takes tissue, cell type and cell state as inputs, pushing prediction from tissue-level to single-cell resolution. Trained on over 107 million single-cell profiles, it nearly doubles the ability to detect gene-expression-related variants, identifying 30% of causal disease variants in an immune-cell benchmark versus 16% for its predecessor. It adds DNA methylation prediction and zero-shot generalization to unseen cell types, and is available via API for non-commercial research.